产品货号：
GS4547
中文名称：
重组人FGF-23
英文名称：
Recombinant Human Fibroblast Growth Factor-23
产品规格：
5μg
发货周期：
1～3天
产品价格：
询价
分子量：Approximately 25.3kDa,a single non-glycosylated polypeptide chain containing 227 amino acids.
储存条件：冷冻（-20℃）
概述
Human FGF-23 belongs to the FGF-19 subfamily which has three members FGF-19,21,23.All FGF family members are heparin binding growth factors with a core 120 amino acid(a.a.)FGF domain that allows for a common tertiary structure.They are classically considered to be paracrine factors and are known for their roles in tissue patterning and organogenesis during embryogenesis.By contrast,the FGF-19 subfamily has recently been shown to function in an endocrine manner.Members of this subfamily have poor ability of binding to heparin binding site which is a crucial factor in ligand-receptor complex formation.β-Klotho has been identified as co-factor required for FGF-19,21,23 signaling.It can obviously increase ligand-receptor affinity.FGF-23 is most highly expressed in bone,from which it circulates through the blood to regulate vitamin D and phosphate metabolism in kidney.
使用说明
This material is offered by Biorab Biotech for research,laboratory or further evaluation purposes.NOT FOR HUMAN USE.
技术规格
相关搜索：重组人FGF-23，FGF-23, Human，Recombinant Human Fibroblast Growth Factor-23
储存条件：冷冻（-20℃）
概述
Human FGF-23 belongs to the FGF-19 subfamily which has three members FGF-19,21,23.All FGF family members are heparin binding growth factors with a core 120 amino acid(a.a.)FGF domain that allows for a common tertiary structure.They are classically considered to be paracrine factors and are known for their roles in tissue patterning and organogenesis during embryogenesis.By contrast,the FGF-19 subfamily has recently been shown to function in an endocrine manner.Members of this subfamily have poor ability of binding to heparin binding site which is a crucial factor in ligand-receptor complex formation.β-Klotho has been identified as co-factor required for FGF-19,21,23 signaling.It can obviously increase ligand-receptor affinity.FGF-23 is most highly expressed in bone,from which it circulates through the blood to regulate vitamin D and phosphate metabolism in kidney.
使用说明
This material is offered by Biorab Biotech for research,laboratory or further evaluation purposes.NOT FOR HUMAN USE.
技术规格
| 外观 | Sterile Filtered White lyophilized(freeze-dried)powder. |
| 纯度 | ＞95%by SDS-PAGE and HPLC analyses. |
| 来源 | Escherichia coli. |
| 生物活性 | Fully biologically active when compared to standard.The ED50 as determined by thymidine uptake assay using FGF-receptors transfected BaF3 cells is less than 0.5μg/ml,corresponding to a specific activity of>2.0×103 IU/mg in the presence of 0.3 μg/ml of rMuKlotho and 10 μg/ml of heparin. |
| 成分 | Lyophilized from a 0.2μmfiltered concentrated solution in PBS,pH 7.4. |
| 内毒素 | Less than 1 EU/μg of rHuFGF-23 as determined by LAL method. |
| 复溶 | We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom.Reconstitute in sterile distilled water or aqueous buffer containing 0.1%BSA to a concentration of 0.1-1.0mg/ml.Stock solutions should be apportioned into working aliquots and stored at ≤ -20 ℃.Further dilutions should be made in appropriate buffered solutions. |
| 氨基酸序列 | YPNASPLLGS SWGGLIHLYT ATARNSYHLQ IHKNGHVDGA PHQTIYSALM IRSEDAGFVV ITGVMSRRYL CMDFRGNIFG SHYFDPENCR FQHQTLENGY DVYHSPQYHF LVSLGRAKRA FLPGMNPPPY SQFLSRRNEI PLIHFNTPIP RRHTRSAEDD SERDPLNVLK PRARMTPAPA SCSQELPSAE DNSPMASDPL GVVRGGRVNT HAGGTGPEGC RPFAKFI |
相关搜索：重组人FGF-23，FGF-23, Human，Recombinant Human Fibroblast Growth Factor-23